6J3P
Crystal structure of the human GCN5 bromodomain in complex with compound (R,R)-36n
Summary for 6J3P
Entry DOI | 10.2210/pdb6j3p/pdb |
Descriptor | Histone acetyltransferase KAT2A, 2-{[(3R,5R)-5-(2,3-dihydro-1,4-benzodioxin-6-yl)-1-methylpiperidin-3-yl]amino}-3-methyl-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one (3 entities in total) |
Functional Keywords | crystal structure of the human gcn5 bromodomain in complex with compound (r, r)-36n, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 32793.55 |
Authors | Huang, L.Y.,Li, H.,Niu, L.,Wu, C.Y.,Yu, Y.M.,Li, L.L.,Yang, S.Y. (deposition date: 2019-01-05, release date: 2019-05-01, Last modification date: 2023-11-22) |
Primary citation | Huang, L.,Li, H.,Li, L.,Niu, L.,Seupel, R.,Wu, C.,Cheng, W.,Chen, C.,Ding, B.,Brennan, P.E.,Yang, S. Discovery of Pyrrolo[3,2- d]pyrimidin-4-one Derivatives as a New Class of Potent and Cell-Active Inhibitors of P300/CBP-Associated Factor Bromodomain. J.Med.Chem., 62:4526-4542, 2019 Cited by PubMed: 30998845DOI: 10.1021/acs.jmedchem.9b00096 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.598 Å) |
Structure validation
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