6J15

Complex structure of GY-5 Fab and PD-1

Summary for 6J15

• Entry DOI: 10.2210/pdb6j15/pdb
• Descriptor: Programmed cell death protein 1, GY-5 heavy chain Fab, GY-5 light chain Fab, ... (6 entities in total)
• Functional Keywords: tumor immunotherapy, complex structure, fg loop, immune system
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 6
• Total formula weight: 124296.08

Authors

Chen, D.,Tan, S.,Zhang, H.,Wang, H.,Chai, Y.,Qi, J.,Yan, J.,Gao, G.F. (deposition date: 2018-12-27, release date: 2019-11-06, Last modification date: 2023-11-22)

• Primary citation: Chen, D.,Tan, S.,Zhang, H.,Wang, H.,He, W.,Shi, R.,Tong, Z.,Zhu, J.,Cheng, H.,Gao, S.,Chai, Y.,Qi, J.,Xiao, M.,Yan, J.,Gao, G.F.; The FG Loop of PD-1 Serves as a "Hotspot" for Therapeutic Monoclonal Antibodies in Tumor Immune Checkpoint Therapy.; Iscience, 14:113-124, 2019; PubMed: 30952089; DOI: 10.1016/j.isci.2019.03.017

Experimental method

X-RAY DIFFRACTION (2.6 Å)