6J0D

Crystal structure of OsSUF4

6J0D の概要

• エントリーDOI: 10.2210/pdb6j0d/pdb
• 分子名称: transcription factor, ZINC ION (3 entities in total)
• 機能のキーワード: transcription factor, transcription
• 由来する生物種: Oryza sativa subsp. japonica (Rice)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 11302.39

構造登録者

Wang, B.,Luo, Q. (登録日: 2018-12-24, 公開日: 2019-11-06, 最終更新日: 2024-11-13)

主引用文献

Liu, B.,Liu, Y.,Wang, B.,Luo, Q.,Shi, J.,Gan, J.,Shen, W.H.,Yu, Y.,Dong, A.
The transcription factor OsSUF4 interacts with SDG725 in promoting H3K36me3 establishment.
Nat Commun, 10:2999-2999, 2019

PubMed Abstract: The different genome-wide distributions of tri-methylation at H3K36 (H3K36me3) in various species suggest diverse mechanisms for H3K36me3 establishment during evolution. Here, we show that the transcription factor OsSUF4 recognizes a specific 7-bp DNA element, broadly distributes throughout the rice genome, and recruits the H3K36 methyltransferase SDG725 to target a set of genes including the key florigen genes RFT1 and Hd3a to promote flowering in rice. Biochemical and structural analyses indicate that several positive residues within the zinc finger domain are vital for OsSUF4 function in planta. Our results reveal a regulatory mechanism contributing to H3K36me3 distribution in plants.

PubMed: 31278262
DOI: 10.1038/s41467-019-10850-5

実験手法

X-RAY DIFFRACTION (1.9 Å)