6IZQ

PRMT4 bound with a bicyclic compound

Summary for 6IZQ

• Entry DOI: 10.2210/pdb6izq/pdb
• Descriptor: Histone-arginine methyltransferase CARM1, (2R)-1-(methylamino)-3-(1,3,4,5-tetrahydro-2-benzazepin-2-yl)propan-2-ol (3 entities in total)
• Functional Keywords: histone-arginine methyltransferase carm1, transferase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 4
• Total formula weight: 151767.51

Authors

Xiong, B.,Cao, D.Y.,Guo, Z.H.,Li, Y.L.,Li, J.,Huang, X.,Shen, J.K. (deposition date: 2018-12-20, release date: 2019-12-25, Last modification date: 2024-03-27)

• Primary citation: Guo, Z.,Zhang, Z.,Yang, H.,Cao, D.,Xu, X.,Zheng, X.,Chen, D.,Wang, Q.,Li, Y.,Li, J.,Du, Z.,Wang, X.,Chen, L.,Ding, J.,Shen, J.,Geng, M.,Huang, X.,Xiong, B.; Design and Synthesis of Potent, Selective Inhibitors of Protein Arginine Methyltransferase 4 against Acute Myeloid Leukemia.; J.Med.Chem., 62:5414-5433, 2019; PubMed: 31117515; DOI: 10.1021/acs.jmedchem.9b00297

Experimental method

X-RAY DIFFRACTION (2.449 Å)