6IZP
Solution structure of the complex of naphthyridine carbamate dimer and an RNA with UGGAA-UGGAA pentad
Summary for 6IZP
Entry DOI | 10.2210/pdb6izp/pdb |
Descriptor | RNA (29-MER), 3-[3-[(7-methyl-1,8-naphthyridin-2-yl)carbamoyloxy]propylamino]propyl ~{N}-(7-methyl-1,8-naphthyridin-2-yl)carbamate (2 entities in total) |
Functional Keywords | sca31, uggaa repeat, small molecule, drug, rna |
Biological source | Homo sapiens |
Total number of polymer chains | 1 |
Total formula weight | 10333.66 |
Authors | Nagano, K.,Shibata, T.,Nakatani, K.,Kawai, G. (deposition date: 2018-12-20, release date: 2019-12-25, Last modification date: 2023-06-14) |
Primary citation | Shibata, T.,Nagano, K.,Ueyama, M.,Ninomiya, K.,Hirose, T.,Nagai, Y.,Ishikawa, K.,Kawai, G.,Nakatani, K. Small molecule targeting r(UGGAA)n disrupts RNA foci and alleviates disease phenotype in Drosophila model Nat Commun, 12:-, 2021 Cited by DOI: 10.1038/s41467-020-20487-4PDB entries with the same primary citation |
Experimental method | SOLUTION NMR |
Structure validation
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