6IVX

Discovery of the Second Generation ROR gamma Inhibitors Composed of an Azole Scaffold.

6IVX の概要

• エントリーDOI: 10.2210/pdb6ivx/pdb
• 分子名称: Nuclear receptor ROR-gamma, Nuclear receptor corepressor 2, (4S)-4-[4'-cyclopropyl-5-(2,2-dimethylpropyl)[3,5'-bi-1,2-oxazol]-3'-yl]-6-[(2,4-dichlorophenyl)amino]-6-oxohexanoic acid, ... (4 entities in total)
• 機能のキーワード: ternary complex, nuclear receptor, nuclear protein, nuclear protein-inhibitor complex, immune system, nuclear protein/inhibitor
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 131554.93

構造登録者

Noguchi, M.,Nomura, A.,Doi, S.,Adachi, T. (登録日: 2018-12-04, 公開日: 2019-03-06, 最終更新日: 2023-11-22)

• 主引用文献: Kotoku, M.,Maeba, T.,Fujioka, S.,Yokota, M.,Seki, N.,Ito, K.,Suwa, Y.,Ikenogami, T.,Hirata, K.,Hase, Y.,Katsuda, Y.,Miyagawa, N.,Arita, K.,Asahina, K.,Noguchi, M.,Nomura, A.,Doi, S.,Adachi, T.,Crowe, P.,Tao, H.,Thacher, S.,Hashimoto, H.,Suzuki, T.,Shiozaki, M.; Discovery of Second Generation ROR gamma Inhibitors Composed of an Azole Scaffold.; J. Med. Chem., 62:2837-2842, 2019; PubMed: 30776227; DOI: 10.1021/acs.jmedchem.8b01567

実験手法

X-RAY DIFFRACTION (2.35 Å)