6ITO

Crystal structure of pyruvate kinase (PYK) from Mycobacterium tuberculosis in complex with Oxalate, AMP and inhibitor Ribose 5-Phosphate

Summary for 6ITO

Entry DOI	10.2210/pdb6ito/pdb
Related	5WSC
Descriptor	Pyruvate kinase, MAGNESIUM ION, OXALATE ION, ... (6 entities in total)
Functional Keywords	pyruvate kinase, glycolysis, tetramer, allostery, synergism, phospho transferase, transferase
Biological source	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Total number of polymer chains	4
Total formula weight	206815.96
Authors	Zhong, W.,Cai, Q.,El Sahili, A.,Mu, Y.,Lescar, J.,Dedon, P.C. (deposition date: 2018-11-24, release date: 2019-08-14, Last modification date: 2023-11-22)
Primary citation	Zhong, W.,Guo, J.,Cui, L.,Chionh, Y.H.,Li, K.,El Sahili, A.,Cai, Q.,Yuan, M.,Michels, P.A.M.,Fothergill-Gilmore, L.A.,Walkinshaw, M.D.,Mu, Y.,Lescar, J.,Dedon, P.C. Pyruvate Kinase Regulates the Pentose-Phosphate Pathway in Response to Hypoxia in Mycobacterium tuberculosis. J.Mol.Biol., 431:3690-3705, 2019 Cited by PubMed: 31381898 DOI: 10.1016/j.jmb.2019.07.033 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.55 Å)

Structure validation