6IRW
Crystal structure of the human cap-specific adenosine methyltransferase bound to SAH
Summary for 6IRW
Entry DOI | 10.2210/pdb6irw/pdb |
Descriptor | Phosphorylated CTD-interacting factor 1, S-ADENOSYL-L-HOMOCYSTEINE (3 entities in total) |
Functional Keywords | rna methylation, methyltransferase, m6a, n6-methyladenosine, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 119554.88 |
Authors | Hirano, S.,Nishimasu, H.,Ishitani, R.,Nureki, O. (deposition date: 2018-11-14, release date: 2018-12-05, Last modification date: 2023-11-22) |
Primary citation | Akichika, S.,Hirano, S.,Shichino, Y.,Suzuki, T.,Nishimasu, H.,Ishitani, R.,Sugita, A.,Hirose, Y.,Iwasaki, S.,Nureki, O.,Suzuki, T. Cap-specific terminal N 6 -methylation of RNA by an RNA polymerase II-associated methyltransferase. Science, 363:-, 2019 Cited by PubMed: 30467178DOI: 10.1126/science.aav0080 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.9 Å) |
Structure validation
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