6IPB

Crystal Structure of the Cofactor-binding Domain of the Human Phase II Drug Metabolism Enzyme UGT2B15

6IPB の概要

• エントリーDOI: 10.2210/pdb6ipb/pdb
• 分子名称: UDP-glucuronosyltransferase 2B15, L(+)-TARTARIC ACID, GLYCEROL, ... (4 entities in total)
• 機能のキーワード: drug metabolism, ugt, glycosyltransferase, tartaric acid, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 86339.26

構造登録者

Zhang, L.,Xie, W.,Wang, C. (登録日: 2018-11-02, 公開日: 2020-01-15, 最終更新日: 2024-03-27)

• 主引用文献: Zhang, L.,Zhu, L.,Qu, W.,Wu, F.,Hu, M.,Xie, W.,Liu, Z.,Wang, C.; Insight into tartrate inhibition patterns in vitro and in vivo based on cocrystal structure with UDP-glucuronosyltransferase 2B15.; Biochem. Pharmacol., 172:113753-113753, 2019; PubMed: 31837310; DOI: 10.1016/j.bcp.2019.113753

実験手法

X-RAY DIFFRACTION (1.78 Å)