6IJS

Human PPARgamma ligand binding domain complexed with SB1494

Summary for 6IJS

• Entry DOI: 10.2210/pdb6ijs/pdb
• Descriptor: Peroxisome proliferator-activated receptor gamma, 16-mer peptide from Nuclear receptor coactivator 1, N-{[3-({[(1R,2S)-2-{[(2E)-2-cyano-4,4-dimethylpent-2-enoyl]amino}cyclopentyl]oxy}methyl)phenyl]methyl}-4-[(4-methylpiperazin-1-yl)methyl]benzamide, ... (4 entities in total)
• Functional Keywords: type 2 diabetes, nuclear receptor, inhibitor, ligand binding domain, transcription
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 33798.33

Authors

Jang, J.Y.,Han, B.W. (deposition date: 2018-10-11, release date: 2019-10-16, Last modification date: 2023-11-22)

• Primary citation: Jang, J.Y.,Kim, H.,Kim, H.J.,Suh, S.W.,Park, S.B.,Han, B.W.; Structural basis for the inhibitory effects of a novel reversible covalent ligand on PPAR gamma phosphorylation.; Sci Rep, 9:11168-11168, 2019; PubMed: 31371757; DOI: 10.1038/s41598-019-47672-w

Experimental method

X-RAY DIFFRACTION (2.15 Å)