6IJI

Crystal structure of PDE10 in complex with inhibitor 2b

Summary for 6IJI

• Entry DOI: 10.2210/pdb6iji/pdb
• Descriptor: cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A, ZINC ION, MAGNESIUM ION, ... (5 entities in total)
• Functional Keywords: hydrolase-inhibitor complex, hydrolase/inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 75730.44

Authors

Huang, Y.Y.,Yu, Y.F.,Zhang, C.,Wu, D.,Wu, Y.,Luo, H.B. (deposition date: 2018-10-10, release date: 2019-04-10, Last modification date: 2023-11-22)

• Primary citation: Huang, Y.Y.,Yu, Y.F.,Zhang, C.,Chen, Y.,Zhou, Q.,Li, Z.,Zhou, S.,Li, Z.,Guo, L.,Wu, D.,Wu, Y.,Luo, H.B.; Validation of Phosphodiesterase-10 as a Novel Target for Pulmonary Arterial Hypertension via Highly Selective and Subnanomolar Inhibitors.; J. Med. Chem., 62:3707-3721, 2019; PubMed: 30888810; DOI: 10.1021/acs.jmedchem.9b00224

Experimental method

X-RAY DIFFRACTION (2.7 Å)