6IJI

Crystal structure of PDE10 in complex with inhibitor 2b

6IJI の概要

• エントリーDOI: 10.2210/pdb6iji/pdb
• 分子名称: cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A, ZINC ION, MAGNESIUM ION, ... (5 entities in total)
• 機能のキーワード: hydrolase-inhibitor complex, hydrolase/inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 75730.44

構造登録者

Huang, Y.Y.,Yu, Y.F.,Zhang, C.,Wu, D.,Wu, Y.,Luo, H.B. (登録日: 2018-10-10, 公開日: 2019-04-10, 最終更新日: 2023-11-22)

• 主引用文献: Huang, Y.Y.,Yu, Y.F.,Zhang, C.,Chen, Y.,Zhou, Q.,Li, Z.,Zhou, S.,Li, Z.,Guo, L.,Wu, D.,Wu, Y.,Luo, H.B.; Validation of Phosphodiesterase-10 as a Novel Target for Pulmonary Arterial Hypertension via Highly Selective and Subnanomolar Inhibitors.; J. Med. Chem., 62:3707-3721, 2019; PubMed: 30888810; DOI: 10.1021/acs.jmedchem.9b00224

実験手法

X-RAY DIFFRACTION (2.7 Å)