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6IJE

Crystal structure of the type VI amidase immunity (Tai4) from Agrobacterium tumefaciens

Summary for 6IJE
Entry DOI10.2210/pdb6ije/pdb
DescriptorTai4, 1,2-ETHANEDIOL (3 entities in total)
Functional Keywordsantitoxin
Biological sourceRhizobium radiobacter (Agrobacterium tumefaciens)
Total number of polymer chains2
Total formula weight23822.78
Authors
Fukuhara, S.,Nakane, T.,Yamashita, K.,Ishii, R.,Ishitani, R.,Nureki, O. (deposition date: 2018-10-09, release date: 2018-12-19, Last modification date: 2024-11-20)
Primary citationFukuhara, S.,Nakane, T.,Yamashita, K.,Ishii, R.,Ishitani, R.,Nureki, O.
Crystal structure of the Agrobacterium tumefaciens type VI effector-immunity complex.
Acta Crystallogr F Struct Biol Commun, 74:810-816, 2018
Cited by
PubMed Abstract: The type VI secretion system (T6SS) comprises needle-shaped multisubunit complexes that play a role in the microbial defense systems of Gram-negative bacteria. Some Gram-negative bacteria harboring a T6SS deliver toxic effector proteins into the cytoplasm or periplasm of competing bacteria in order to lyse and kill them. To avoid self-cell disruption, these bacteria have cognate immunity proteins that inhibit their toxic effector proteins. T6SS amidase effector protein 4 (Tae4) and T6SS amidase immunity protein 4 (Tai4) are a representative of the toxic effector-immunity pairs of the T6SS. Here, the three-dimensional structures of Tai4 and the Tae4-Tai4 complex from Agrobacterium tumefaciens are reported at 1.55 and 1.9 Å resolution, respectively. A structural comparison with other Tae4-Tai4 homologs revealed similarities and differences in the catalytic and inhibitory mechanisms among the Tae4 and Tai4 family proteins.
PubMed: 30511676
DOI: 10.1107/S2053230X18016369
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.55 Å)
Structure validation

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