6IIY

Crystal structure of deacetylase triple mutant (Orf2*T) that involving in teicoplanin biosynthetic pathway

Summary for 6IIY

• Entry DOI: 10.2210/pdb6iiy/pdb
• Descriptor: deacetylase, IMIDAZOLE, COBALT (II) ION, ... (4 entities in total)
• Functional Keywords: antibiotics, oxidoreductase
• Biological source: Actinoplanes teichomyceticus
• Total number of polymer chains: 1
• Total formula weight: 32378.78

Authors

Li, T.L.,Huang, C.M. (deposition date: 2018-10-08, release date: 2019-10-09, Last modification date: 2023-11-22)

• Primary citation: Huang, C.M.,Lyu, S.Y.,Lin, K.H.,Chen, C.L.,Chen, M.H.,Shih, H.W.,Hsu, N.S.,Lo, I.W.,Wang, Y.L.,Li, Y.S.,Wu, C.J.,Li, T.L.; Teicoplanin Reprogrammed with the N-Acyl-Glucosamine Pharmacophore at the Penultimate Residue of Aglycone Acquires Broad-Spectrum Antimicrobial Activities Effectively Killing Gram-Positive and -Negative Pathogens.; Acs Infect Dis., 5:430-442, 2019; PubMed: 30599088; DOI: 10.1021/acsinfecdis.8b00317

Experimental method

X-RAY DIFFRACTION (1.29 Å)