6IIK

USP14 catalytic domain with IU1

Summary for 6IIK

Entry DOI	10.2210/pdb6iik/pdb
Descriptor	Ubiquitin carboxyl-terminal hydrolase 14, 1-[1-(4-fluorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl]-2-(pyrrolidin-1-yl)ethan-1-one (3 entities in total)
Functional Keywords	usp14 inhibitor complex, structural protein, hydrolase
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	91810.27
Authors	Mei, Z.Q.,Wang, Y.W.,He, W.,Wang, F. (deposition date: 2018-10-06, release date: 2018-12-12, Last modification date: 2023-11-22)
Primary citation	Wang, Y.,Jiang, Y.,Ding, S.,Li, J.,Song, N.,Ren, Y.,Hong, D.,Wu, C.,Li, B.,Wang, F.,He, W.,Wang, J.,Mei, Z. Small molecule inhibitors reveal allosteric regulation of USP14 via steric blockade. Cell Res., 28:1186-1194, 2018 Cited by PubMed: 30254335 DOI: 10.1038/s41422-018-0091-x PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.97 Å)

Structure validation