6IDF

Cryo-EM structure of gamma secretase in complex with a Notch fragment

Summary for 6IDF

• Entry DOI: 10.2210/pdb6idf/pdb
• EMDB information: 3061 3237 3238 3239 3240 9648
• Descriptor: Nicastrin, CHOLESTEROL, Presenilin-1, ... (10 entities in total)
• Functional Keywords: complex, membrane protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 5
• Total formula weight: 195623.20

Authors

Yang, G.,Zhou, R.,Zhou, Q.,Guo, X.,Yan, C.,Ke, M.,Lei, J.,Shi, Y. (deposition date: 2018-09-09, release date: 2018-12-26, Last modification date: 2020-07-29)

• Primary citation: Yang, G.,Zhou, R.,Zhou, Q.,Guo, X.,Yan, C.,Ke, M.,Lei, J.,Shi, Y.; Structural basis of Notch recognition by human gamma-secretase; Nature, 565:192-197, 2019; PubMed: 30598546; DOI: 10.1038/s41586-018-0813-8

Experimental method

ELECTRON MICROSCOPY (2.7 Å)