6IC5

Human cathepsin-C in complex with dipeptidyl cyclopropyl nitrile inhibitor 2

Summary for 6IC5

Entry DOI	10.2210/pdb6ic5/pdb
Descriptor	Dipeptidyl peptidase 1, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total)
Functional Keywords	cathepsin-c, cysteine protease, structure-based drug design, arthritis, hydrolase
Biological source	Homo sapiens (Human) More
Total number of polymer chains	3
Total formula weight	41326.63
Authors	Hakansson, M.,Logan, D.T.,Korkmaz, B.,Lesner, A.,Wysocka, M.,Gieldon, A.,Gauthier, F.,Jenne, D.,Lauritzen, C.,Pedersen, J. (deposition date: 2018-12-02, release date: 2019-04-24, Last modification date: 2020-07-29)
Primary citation	Korkmaz, B.,Lesner, A.,Wysocka, M.,Gieldon, A.,Hakansson, M.,Gauthier, F.,Logan, D.T.,Jenne, D.E.,Lauritzen, C.,Pedersen, J. Structure-based design and in vivo anti-arthritic activity evaluation of a potent dipeptidyl cyclopropyl nitrile inhibitor of cathepsin C. Biochem. Pharmacol., 164:349-367, 2019 Cited by PubMed: 30978322 DOI: 10.1016/j.bcp.2019.04.006 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation