6IC5
Human cathepsin-C in complex with dipeptidyl cyclopropyl nitrile inhibitor 2
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Dipeptidyl peptidase 1 | polymer | 119 | 13500.2 | 1 | UniProt (P53634) Pfam (PF08773) | Homo sapiens (Human) | Cathepsin C,Cathepsin J,Dipeptidyl peptidase I,DPPI,Dipeptidyl transferase |
| 2 | B (B) | Dipeptidyl peptidase 1 | polymer | 162 | 18302.6 | 1 | UniProt (P53634) Pfam (PF00112) | Homo sapiens (Human) | Cathepsin C,Cathepsin J,Dipeptidyl peptidase I,DPPI,Dipeptidyl transferase |
| 3 | C (C) | Dipeptidyl peptidase 1 | polymer | 69 | 7583.4 | 1 | UniProt (P53634) | Homo sapiens (Human) | Cathepsin C,Cathepsin J,Dipeptidyl peptidase I,DPPI,Dipeptidyl transferase |
| 4 | D (D) | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 1 | In PDB GlyTouCan (G42227JK) | |||
| 5 | E, F (A, B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) | |||
| 6 | G (B) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 7 | H (B) | (2~{S})-2-azanyl-~{N}-[(1~{R},2~{R})-1-(iminomethyl)-2-[4-[4-(4-methylpiperazin-1-yl)sulfonylphenyl]phenyl]cyclopropyl]-3-thiophen-2-yl-propanamide | non-polymer | 551.7 | 1 | Chemie (HB5) | |||
| 8 | I, J, K (A, B, C) | water | water | 18.0 | 372 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 39386.2 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 910.8 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1029.6 | |
| All* | Total formula weight | 41326.6 |
