6IBV
Crystal structure of NDM-1 beta-lactamase in complex with broad spectrum boronic inhibitor cpd 1
Summary for 6IBV
Entry DOI | 10.2210/pdb6ibv/pdb |
Descriptor | Metallo-beta-lactamase type 2, [5-(bromomethyl)-1-benzothiophen-2-yl]-tris(oxidanyl)boranuide, ZINC ION, ... (7 entities in total) |
Functional Keywords | beta-lactamase; bacterial resistance; acyclic boronic inhibitors, hydrolase |
Biological source | Klebsiella pneumoniae |
Total number of polymer chains | 2 |
Total formula weight | 52780.47 |
Authors | Maso, L.,Quotadamo, A.,Bellio, P.,Montanari, M.,Celenza, G.,Venturelli, A.,Costi, M.P.,Tondi, D.,Cendron, L. (deposition date: 2018-11-30, release date: 2019-05-15, Last modification date: 2019-10-30) |
Primary citation | Cendron, L.,Quotadamo, A.,Maso, L.,Bellio, P.,Montanari, M.,Celenza, G.,Venturelli, A.,Costi, M.P.,Tondi, D. X-ray Crystallography Deciphers the Activity of Broad-Spectrum Boronic Acid beta-Lactamase Inhibitors. Acs Med.Chem.Lett., 10:650-655, 2019 Cited by PubMed: 30996812DOI: 10.1021/acsmedchemlett.8b00607 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.4 Å) |
Structure validation
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