6IAR
Tricyclic indazoles a novel class of selective estrogen receptor degrader antagonists
Summary for 6IAR
Entry DOI | 10.2210/pdb6iar/pdb |
Descriptor | Estrogen receptor, 3-[4-[(6~{R})-7-(2-methylpropyl)-3,6,8,9-tetrahydropyrazolo[4,3-f]isoquinolin-6-yl]phenyl]propanoic acid (3 entities in total) |
Functional Keywords | nuclear hormone receptor inhibitor downregulation estrogen receptor modulators, dna binding protein |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 27470.29 |
Authors | Scott, J.S.,Bailey, A.,Buttar, D.,Carbajo, R.J.,Curwen, J.,Davies, R.D.M.,Degorce, S.L.,Donald, C.,Gangl, E.,Greenwood, R.,Groombridge, S.D.,Johnson, T.,Lamont, S.,Lawson, M.,Lister, A.,Morrow, C.,Moss, T.,Pink, J.H.,Polanski, R. (deposition date: 2018-11-27, release date: 2019-01-23, Last modification date: 2024-05-15) |
Primary citation | Scott, J.S.,Bailey, A.,Buttar, D.,Carbajo, R.J.,Curwen, J.,Davey, P.R.J.,Davies, R.D.M.,Degorce, S.L.,Donald, C.,Gangl, E.,Greenwood, R.,Groombridge, S.D.,Johnson, T.,Lamont, S.,Lawson, M.,Lister, A.,Morrow, C.J.,Moss, T.A.,Pink, J.H.,Polanski, R. Tricyclic Indazoles-A Novel Class of Selective Estrogen Receptor Degrader Antagonists. J.Med.Chem., 62:1593-1608, 2019 Cited by PubMed: 30640465DOI: 10.1021/acs.jmedchem.8b01837 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.84 Å) |
Structure validation
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