6I9L

JmjC domain-containing protein 5 (JMJD5) in complex with Mn and pyridine-2,4-dicarboxylic acid (2,4-PDCA)

Summary for 6I9L

Entry DOI	10.2210/pdb6i9l/pdb
Descriptor	JmjC domain-containing protein 5, MANGANESE (II) ION, PYRIDINE-2,4-DICARBOXYLIC ACID, ... (5 entities in total)
Functional Keywords	oxidoreductase, non-heme, iron, 2-oxoglutarate, dioxygenase, jmjc, jmjc domain, lysine-specific demethylase 8, jmjc domain-containing protein 5, arginyl c-3 hydroxylase, jmjd5, kdm8, oxygenase, hypoxia, dna-binding, metal-binding, translation, dsbh, facial triad, cytoplasm, jmjc hydroxylase, jmjc demethylase, kdms, post-translational modifications, ptm, beta-hydroxylation, hydroxylation, arginine hydroxylation, rcc1 domain-containing protein 1, rccd1, regulator of chromosome condensation, 40s ribosomal protein s6, rps6, ribosome biogenesis, transcription, epigenetic regulation, signaling, development, cell structure, transcription activator/inhibitor, phosphorylation, cancer, polymorphism
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	30077.75
Authors	Chowdhury, R.,Islam, M.S.,Schofield, C.J. (deposition date: 2018-11-23, release date: 2019-12-04, Last modification date: 2024-01-31)
Primary citation	Islam, M.S.,Markoulides, M.,Chowdhury, R.,Schofield, C.J. Structural analysis of the 2-oxoglutarate binding site of the circadian rhythm linked oxygenase JMJD5. Sci Rep, 12:20680-20680, 2022 Cited by PubMed: 36450832 DOI: 10.1038/s41598-022-24154-0 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.53 Å)

Structure validation