6I8Z

Crystal structure of PTK2 in complex with BI-4464.

Summary for 6I8Z

Entry DOI	10.2210/pdb6i8z/pdb
Descriptor	Focal adhesion kinase 1, 3-methoxy-~{N}-(1-methylpiperidin-1-ium-4-yl)-4-[[4-[(3-oxidanylidene-1,2-dihydroinden-4-yl)oxy]-5-(trifluoromethyl)pyrimidin-2-yl]amino]benzamide (3 entities in total)
Functional Keywords	inhibitor, protein kinase, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	32803.73
Authors	Bader, G.,Zoephel, A. (deposition date: 2018-11-21, release date: 2019-02-20, Last modification date: 2024-01-24)
Primary citation	Popow, J.,Arnhof, H.,Bader, G.,Berger, H.,Ciulli, A.,Covini, D.,Dank, C.,Gmaschitz, T.,Greb, P.,Karolyi-Ozguer, J.,Koegl, M.,McConnell, D.B.,Pearson, M.,Rieger, M.,Rinnenthal, J.,Roessler, V.,Schrenk, A.,Spina, M.,Steurer, S.,Trainor, N.,Traxler, E.,Wieshofer, C.,Zoephel, A.,Ettmayer, P. Highly Selective PTK2 Proteolysis Targeting Chimeras to Probe Focal Adhesion Kinase Scaffolding Functions. J.Med.Chem., 62:2508-2520, 2019 Cited by PubMed: 30739444 DOI: 10.1021/acs.jmedchem.8b01826 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.99 Å)

Structure validation