6I8Z

Crystal structure of PTK2 in complex with BI-4464.

6I8Z の概要

• エントリーDOI: 10.2210/pdb6i8z/pdb
• 分子名称: Focal adhesion kinase 1, 3-methoxy-~{N}-(1-methylpiperidin-1-ium-4-yl)-4-[[4-[(3-oxidanylidene-1,2-dihydroinden-4-yl)oxy]-5-(trifluoromethyl)pyrimidin-2-yl]amino]benzamide (3 entities in total)
• 機能のキーワード: inhibitor, protein kinase, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 32803.73

構造登録者

Bader, G.,Zoephel, A. (登録日: 2018-11-21, 公開日: 2019-02-20, 最終更新日: 2024-01-24)

• 主引用文献: Popow, J.,Arnhof, H.,Bader, G.,Berger, H.,Ciulli, A.,Covini, D.,Dank, C.,Gmaschitz, T.,Greb, P.,Karolyi-Ozguer, J.,Koegl, M.,McConnell, D.B.,Pearson, M.,Rieger, M.,Rinnenthal, J.,Roessler, V.,Schrenk, A.,Spina, M.,Steurer, S.,Trainor, N.,Traxler, E.,Wieshofer, C.,Zoephel, A.,Ettmayer, P.; Highly Selective PTK2 Proteolysis Targeting Chimeras to Probe Focal Adhesion Kinase Scaffolding Functions.; J.Med.Chem., 62:2508-2520, 2019; PubMed: 30739444; DOI: 10.1021/acs.jmedchem.8b01826

実験手法

X-RAY DIFFRACTION (1.99 Å)