6I8S

Discovery and characterisation of an antibody that selectively modulates the inhibitory activity of plasminogen activator inhibitor-1

Summary for 6I8S

DescriptorPlasminogen activator inhibitor 1, HEAVY CHAIN OF FAB FRAGMENT FROM AN PAI-1 ANTIBODY, LIGHT CHAIN OF FAB FRAGMENT FROM AN PAI-1 ANTIBODY, ... (4 entities in total)
Functional Keywordsserpin, plasminogen activator inhibitor-1, pai-1, antibody, fab, blood clotting
Biological sourceHomo sapiens (Human)
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Total number of polymer chains12
Total molecular weight359762.65
Authors
Vousden, K.A.,Lundqvist, T.,Popovic, B. (deposition date: 2018-11-21, release date: 2019-02-13, Last modification date: 2019-02-20)
Primary citation
Vousden, K.A.,Lundqvist, T.,Popovic, B.,Naiman, B.,Carruthers, A.M.,Newton, P.,Johnson, D.J.D.,Pomowski, A.,Wilkinson, T.,Dufner, P.,de Mendez, I.,Mallinder, P.R.,Murray, C.,Strain, M.,Connor, J.,Murray, L.A.,Sleeman, M.A.,Lowe, D.C.,Huntington, J.A.,Vaughan, T.J.
Discovery and characterisation of an antibody that selectively modulates the inhibitory activity of plasminogen activator inhibitor-1.
Sci Rep, 9:1605-1605, 2019
PubMed: 30733557 (PDB entries with the same primary citation)
DOI: 10.1038/s41598-019-38842-x
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.9 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.2537 0.5% 7.0% 4.7%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 6i8s
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Molmil generated image of 6i8s
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Molmil generated image of 6i8s
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