6I8L

Crystal structure of Spindlin1 in complex with the inhibitor TD001851a

6I8L の概要

• エントリーDOI: 10.2210/pdb6i8l/pdb
• 分子名称: Spindlin-1, (4S)-2-METHYL-2,4-PENTANEDIOL, (4R)-2-METHYLPENTANE-2,4-DIOL, ... (7 entities in total)
• 機能のキーワード: epigenetics, tudor domain, methyl-lysine, methyl-arginine, cell cycle
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 26281.28

構造登録者

Johansson, C.,Fagan, V.,Brennan, P.E.,Sorrell, F.J.,Krojer, T.,Arrowsmith, C.H.,Bountra, C.,Edwards, A.,Oppermann, U.C.T. (登録日: 2018-11-20, 公開日: 2018-12-05, 最終更新日: 2024-01-24)

• 主引用文献: Fagan, V.,Johansson, C.,Gileadi, C.,Monteiro, O.,Dunford, J.E.,Nibhani, R.,Philpott, M.,Malzahn, J.,Wells, G.,Faram, R.,Cribbs, A.P.,Halidi, N.,Li, F.,Chau, I.,Greschik, H.,Velupillai, S.,Allali-Hassani, A.,Bennett, J.,Christott, T.,Giroud, C.,Lewis, A.M.,Huber, K.V.M.,Athanasou, N.,Bountra, C.,Jung, M.,Schule, R.,Vedadi, M.,Arrowsmith, C.,Xiong, Y.,Jin, J.,Fedorov, O.,Farnie, G.,Brennan, P.E.,Oppermann, U.; A Chemical Probe for Tudor Domain Protein Spindlin1 to Investigate Chromatin Function.; J.Med.Chem., 62:9008-9025, 2019; PubMed: 31550156; DOI: 10.1021/acs.jmedchem.9b00562

実験手法

X-RAY DIFFRACTION (1.58 Å)