6I8B
Crystal structure of Spindlin1 in complex with the inhibitor VinSpinIn
Summary for 6I8B
Entry DOI | 10.2210/pdb6i8b/pdb |
Descriptor | Spindlin-1, 2-[4-[2-[[2-[3-[2-azanyl-5-(cyclopropylmethoxy)-3,3-dimethyl-indol-6-yl]oxypropyl]-1,3-dihydroisoindol-5-yl]oxy]ethyl]-1,2,3-triazol-1-yl]-1-[4-(2-pyrrolidin-1-ylethyl)piperidin-1-yl]ethanone, DIMETHYL SULFOXIDE, ... (6 entities in total) |
Functional Keywords | epigenetics, tudor domain, methyl-lysine, methyl-arginine, cell cycle |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 53113.25 |
Authors | Johansson, C.,Fagan, V.,Brennan, P.E.,Sorrell, F.J.,Krojer, T.,Arrowsmith, C.H.,Bountra, C.,Edwards, A.,Oppermann, U.C.T. (deposition date: 2018-11-19, release date: 2018-12-05, Last modification date: 2024-01-24) |
Primary citation | Fagan, V.,Johansson, C.,Gileadi, C.,Monteiro, O.,Dunford, J.E.,Nibhani, R.,Philpott, M.,Malzahn, J.,Wells, G.,Faram, R.,Cribbs, A.P.,Halidi, N.,Li, F.,Chau, I.,Greschik, H.,Velupillai, S.,Allali-Hassani, A.,Bennett, J.,Christott, T.,Giroud, C.,Lewis, A.M.,Huber, K.V.M.,Athanasou, N.,Bountra, C.,Jung, M.,Schule, R.,Vedadi, M.,Arrowsmith, C.,Xiong, Y.,Jin, J.,Fedorov, O.,Farnie, G.,Brennan, P.E.,Oppermann, U. A Chemical Probe for Tudor Domain Protein Spindlin1 to Investigate Chromatin Function. J.Med.Chem., 62:9008-9025, 2019 Cited by PubMed: 31550156DOI: 10.1021/acs.jmedchem.9b00562 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.76 Å) |
Structure validation
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