6I7X
Crystal Structure of the first bromodomain of BRD4 in complex with RT53
Summary for 6I7X
Entry DOI | 10.2210/pdb6i7x/pdb |
Descriptor | Bromodomain-containing protein 4, 1,2-ETHANEDIOL, 2-[(4~{S})-6-(4-chlorophenyl)-8-methoxy-1-methyl-4~{H}-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]-1-[4-(dimethylamino)piperidin-1-yl]ethanone, ... (4 entities in total) |
Functional Keywords | bet, bromodomain, rt53, inhibitor, structural genomics, structural genomics consortium, sgc, transcription |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 15792.61 |
Authors | Picaud, S.,Traquete, R.,Bernardes, G.J.L.,Newman, J.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Filippakopoulos, P.,Structural Genomics Consortium (SGC) (deposition date: 2018-11-19, release date: 2019-11-27, Last modification date: 2024-01-24) |
Primary citation | Picaud, S.,Traquete, R.,Bernardes, G.J.L.,Newman, J.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Filippakopoulos, P.,Structural Genomics Consortium (SGC) Crystal Structure of the first bromodomain of BRD4 in complex with RT53 To Be Published, |
Experimental method |
Structure validation
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