6I78

Galectin-3C in complex with substituted polyfluoroaryl monothiogalactoside derivative 5

Summary for 6I78

Entry DOI	10.2210/pdb6i78/pdb
Descriptor	Galectin-3, (2~{R},3~{R},4~{S},5~{R},6~{S})-2-(hydroxymethyl)-6-(4-methylphenyl)sulfanyl-4-[4-[2,3,5,6-tetrakis(fluoranyl)-4-(methylamino)phenyl]-1,2,3-triazol-1-yl]oxane-3,5-diol (3 entities in total)
Functional Keywords	lectin, carbohydrate-binding protein, galactose-specific lectin 3, galactoside-binding protein, galbp, ige-6 binding protein, l-31, laminin-binding protein, lectin l-29, mac-2, sugar binding protein
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	16215.54
Authors	Kumar, R.,Peterson, K.,Nilsson, U.J.,Logan, D.T. (deposition date: 2018-11-15, release date: 2019-01-23, Last modification date: 2024-01-24)
Primary citation	Kumar, R.,Peterson, K.,Misini Ignjatovic, M.,Leffler, H.,Ryde, U.,Nilsson, U.J.,Logan, D.T. Substituted polyfluoroaryl interactions with an arginine side chain in galectin-3 are governed by steric-, desolvation and electronic conjugation effects. Org. Biomol. Chem., 17:1081-1089, 2019 Cited by PubMed: 30632578 DOI: 10.1039/c8ob02888e PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.15 Å)

Structure validation