6I5Y
Crystal structure of E. coli tyrRS in complex with 5'-O-(N-L-tyrosyl)sulfamoyl-adenosine
Summary for 6I5Y
Entry DOI | 10.2210/pdb6i5y/pdb |
Related | 6HB5 6HB6 6HB7 |
Descriptor | Tyrosine--tRNA ligase, 5'-O-[N-(L-TYROSYL)SULFAMOYL]ADENOSINE, 1,2-ETHANEDIOL, ... (4 entities in total) |
Functional Keywords | protein-inhibitor complex, rossmann fold, trna aminoacylation, ligase |
Biological source | Escherichia coli BL21(DE3) |
Total number of polymer chains | 2 |
Total formula weight | 96394.85 |
Authors | De Graef, S.,Pang, L.,Strelkov, S.V.,Weeks, S.D. (deposition date: 2018-11-15, release date: 2019-04-17, Last modification date: 2024-01-24) |
Primary citation | Nautiyal, M.,De Graef, S.,Pang, L.,Gadakh, B.,Strelkov, S.V.,Weeks, S.D.,Van Aerschot, A. Comparative analysis of pyrimidine substituted aminoacyl-sulfamoyl nucleosides as potential inhibitors targeting class I aminoacyl-tRNA synthetases. Eur.J.Med.Chem., 173:154-166, 2019 Cited by PubMed: 30995568DOI: 10.1016/j.ejmech.2019.04.003 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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