Crystal structure of the wild-type SucA domain of Mycobacterium smegmatis KGD (alpha-ketoglutarate decarboxylase), in complex with GarA

Replaces:  2XT9

Summary for 6I2Q

DescriptorMultifunctional 2-oxoglutarate metabolism enzyme, Glycogen accumulation regulator GarA, THIAMINE DIPHOSPHATE, ... (6 entities in total)
Functional Keywordsoxoglutarate dehydrogenase, decarboxylase, oxidoreductase
Biological sourceMycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Total number of polymer chains2
Total molecular weight109768.64
Wagner, T.,Bellinzoni, M.,Alzari, P.M. (deposition date: 2018-11-01, release date: 2019-05-22)
Primary citation
Wagner, T.,Andre-Leroux, G.,Hindie, V.,Barilone, N.,Lisa, M.N.,Hoos, S.,Raynal, B.,Vulliez-Le Normand, B.,O'Hare, H.M.,Bellinzoni, M.,Alzari, P.M.
Structural insights into the functional versatility of an FHA domain protein in mycobacterial signaling.
Sci.Signal., 12:-, 2019
PubMed: 31064884 (PDB entries with the same primary citation)
DOI: 10.1126/scisignal.aav9504
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.19210 0.8% 6.7%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution