6I1S

Crystal structure of the ACVR1 (ALK2) kinase in complex with FKBP12 and the inhibitor E6201

Summary for 6I1S

• Entry DOI: 10.2210/pdb6i1s/pdb
• Descriptor: Activin receptor type-1, Peptidyl-prolyl cis-trans isomerase FKBP1A, (4~{S},5~{R},6~{Z},9~{S},10~{S},12~{E})-16-(ethylamino)-4,5-dimethyl-9,10,18-tris(oxidanyl)-3-oxabicyclo[12.4.0]octadeca-1(14),6,12,15,17-pentaene-2,8-dione, ... (6 entities in total)
• Functional Keywords: kinase, inhibitor, alk2, acvr1, fkbp12, complex, signaling protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 50469.57

Authors

Williams, E.P.,Pinkas, D.M.,Fortin, J.,Newman, J.A.,Bradshaw, W.J.,Mahajan, P.,Kupinska, K.,Burgess-Brown, N.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Bullock, A.N. (deposition date: 2018-10-30, release date: 2019-09-11, Last modification date: 2024-01-24)

• Primary citation: Fortin, J.,Tian, R.,Zarrabi, I.,Hill, G.,Williams, E.,Sanchez-Duffhues, G.,Thorikay, M.,Ramachandran, P.,Siddaway, R.,Wong, J.F.,Wu, A.,Apuzzo, L.N.,Haight, J.,You-Ten, A.,Snow, B.E.,Wakeham, A.,Goldhamer, D.J.,Schramek, D.,Bullock, A.N.,Dijke, P.T.,Hawkins, C.,Mak, T.W.; Mutant ACVR1 Arrests Glial Cell Differentiation to Drive Tumorigenesis in Pediatric Gliomas.; Cancer Cell, 37:308-323.e12, 2020; PubMed: 32142668; DOI: 10.1016/j.ccell.2020.02.002

Experimental method

X-RAY DIFFRACTION (1.52 Å)