6I0J
Crystal structure of human carbonic anhydrase I in complex with the 4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)phenyl sulfamate inhibitor
Summary for 6I0J
Entry DOI | 10.2210/pdb6i0j/pdb |
Descriptor | Carbonic anhydrase 1, ZINC ION, ACETATE ION, ... (6 entities in total) |
Functional Keywords | carbonic anhydrase i, inhibitor, lyase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 59157.10 |
Authors | Ferraroni, M.,Supuran, C.T.,Bozdag, M.,Chiapponi, D. (deposition date: 2018-10-26, release date: 2019-11-20, Last modification date: 2024-01-24) |
Primary citation | Bozdag, M.,Ferraroni, M.,Ward, C.,Carta, F.,Bua, S.,Angeli, A.,Langdon, S.P.,Kunkler, I.H.,Al-Tamimi, A.S.,Supuran, C.T. Carbonic anhydrase inhibitors based on sorafenib scaffold: Design, synthesis, crystallographic investigation and effects on primary breast cancer cells. Eur.J.Med.Chem., 182:111600-111600, 2019 Cited by PubMed: 31419777DOI: 10.1016/j.ejmech.2019.111600 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.35 Å) |
Structure validation
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