6I07

Crystal structure of EpCAM in complex with scFv

Summary for 6I07

Entry DOI	10.2210/pdb6i07/pdb
Descriptor	Single chain Fv, Epithelial cell adhesion molecule, GLYCEROL, ... (4 entities in total)
Functional Keywords	immune system, single chain fv, scfv, epcam
Biological source	Homo sapiens (Human) More
Total number of polymer chains	4
Total formula weight	113052.58
Authors	Casaletto, J.B.,Geddie, M.L.,Abu-Yousif, A.O.,Masson, K.,Fulgham, A.,Boudot, A.,Maiwald, T.,Kearns, J.D.,Kohli, N.,Su, S.,Razlog, M.,Raue, A.,Kalra, A.,Hakansson, M.,Logan, D.T.,Welin, M.,Chattopadhyay, S.,Harms, B.D.,Nielsen, U.B.,Schoeberl, B.,Lugovskoy, A.A.,MacBeath, G. (deposition date: 2018-10-25, release date: 2019-03-13, Last modification date: 2024-01-24)
Primary citation	Casaletto, J.B.,Geddie, M.L.,Abu-Yousif, A.O.,Masson, K.,Fulgham, A.,Boudot, A.,Maiwald, T.,Kearns, J.D.,Kohli, N.,Su, S.,Razlog, M.,Raue, A.,Kalra, A.,Hakansson, M.,Logan, D.T.,Welin, M.,Chattopadhyay, S.,Harms, B.D.,Nielsen, U.B.,Schoeberl, B.,Lugovskoy, A.A.,MacBeath, G. MM-131, a bispecific anti-Met/EpCAM mAb, inhibits HGF-dependent and HGF-independent Met signaling through concurrent binding to EpCAM. Proc.Natl.Acad.Sci.USA, 116:7533-7542, 2019 Cited by PubMed: 30898885 DOI: 10.1073/pnas.1819085116 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.35 Å)

Structure validation