6I07
Crystal structure of EpCAM in complex with scFv
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Single chain Fv | polymer | 262 | 27857.9 | 2 | Homo sapiens (Human) | ||
2 | C, D | Epithelial cell adhesion molecule | polymer | 253 | 28622.4 | 2 | UniProt (P16422) Pfam (PF18635) Pfam (PF00086) Pfam (PF21283) In PDB | Homo sapiens (Human) | Ep-CAM,Adenocarcinoma-associated antigen,Cell surface glycoprotein Trop-1,Epithelial cell surface antigen,Epithelial glycoprotein,EGP,Epithelial glycoprotein 314,hEGP314,KS 1/4 antigen,KSA,Major gastrointestinal tumor-associated protein GA733-2,Tumor-associated calcium signal transducer 1 |
3 | A | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
4 | water | water | 18.0 | 117 | Chemie (HOH) |
Sequence modifications
C, D: 25 - 265 (UniProt: P16422)
PDB | External Database | Details |
---|---|---|
Gln 74 | Asn 74 | engineered mutation |
Gln 111 | Asn 111 | engineered mutation |
Gln 198 | Asn 198 | engineered mutation |
Gly 266 | - | expression tag |
Gly 267 | - | expression tag |
Gly 268 | - | expression tag |
Gly 269 | - | expression tag |
Ser 270 | - | expression tag |
His 271 | - | expression tag |
His 272 | - | expression tag |
His 273 | - | expression tag |
His 274 | - | expression tag |
His 275 | - | expression tag |
His 276 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 112960.5 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 92.1 | |
All* | Total formula weight | 113052.6 |