6I04

Crystal structure of Sema domain of the Met receptor in complex with FAB

Summary for 6I04

Entry DOI	10.2210/pdb6i04/pdb
Descriptor	Hepatocyte growth factor receptor, Fab heavy chain, Fab light chain (3 entities in total)
Functional Keywords	immune system, met, sema domain
Biological source	Homo sapiens (Human) More
Total number of polymer chains	6
Total formula weight	219995.70
Authors	Casaletto, J.B.,Geddie, M.L.,Abu-Yousif, A.O.,Masson, K.,Fulgham, A.,Boudot, A.,Maiwald, T.,Kearns, J.D.,Kohli, N.,Su, S.,Razlog, M.,Raue, A.,Kalra, A.,Hakansson, M.,Logan, D.T.,Welin, M.,Chattopadhyay, S.,Harms, B.D.,Nielsen, U.B.,Schoeberl, B.,Lugovskoy, A.A.,MacBeath, G. (deposition date: 2018-10-25, release date: 2019-03-13, Last modification date: 2024-01-24)
Primary citation	Casaletto, J.B.,Geddie, M.L.,Abu-Yousif, A.O.,Masson, K.,Fulgham, A.,Boudot, A.,Maiwald, T.,Kearns, J.D.,Kohli, N.,Su, S.,Razlog, M.,Raue, A.,Kalra, A.,Hakansson, M.,Logan, D.T.,Welin, M.,Chattopadhyay, S.,Harms, B.D.,Nielsen, U.B.,Schoeberl, B.,Lugovskoy, A.A.,MacBeath, G. MM-131, a bispecific anti-Met/EpCAM mAb, inhibits HGF-dependent and HGF-independent Met signaling through concurrent binding to EpCAM. Proc.Natl.Acad.Sci.USA, 116:7533-7542, 2019 Cited by PubMed: 30898885 DOI: 10.1073/pnas.1819085116 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.1 Å)

Structure validation