6HXM

Structure of the citryl-CoA lyase core module of human ATP citrate lyase in complex with citrate and CoASH in space group C2221

Summary for 6HXM

Entry DOI	10.2210/pdb6hxm/pdb
Descriptor	ATP-citrate synthase, COENZYME A, CITRATE ANION, ... (4 entities in total)
Functional Keywords	atp citrate lyase, central metabolism, acetyl-coa, citrate shuttle, rtca cycle, citryl-coa, lipogenesis, lyase
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	61929.32
Authors	Verstraete, K.,Verschueren, K. (deposition date: 2018-10-17, release date: 2019-04-10, Last modification date: 2024-05-01)
Primary citation	Verschueren, K.H.G.,Blanchet, C.,Felix, J.,Dansercoer, A.,De Vos, D.,Bloch, Y.,Van Beeumen, J.,Svergun, D.,Gutsche, I.,Savvides, S.N.,Verstraete, K. Structure of ATP citrate lyase and the origin of citrate synthase in the Krebs cycle. Nature, 568:571-575, 2019 Cited by PubMed: 30944476 DOI: 10.1038/s41586-019-1095-5 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.3 Å)

Structure validation