6HXM

Structure of the citryl-CoA lyase core module of human ATP citrate lyase in complex with citrate and CoASH in space group C2221

6HXM の概要

• エントリーDOI: 10.2210/pdb6hxm/pdb
• 分子名称: ATP-citrate synthase, COENZYME A, CITRATE ANION, ... (4 entities in total)
• 機能のキーワード: atp citrate lyase, central metabolism, acetyl-coa, citrate shuttle, rtca cycle, citryl-coa, lipogenesis, lyase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 61929.32

構造登録者

Verstraete, K.,Verschueren, K. (登録日: 2018-10-17, 公開日: 2019-04-10, 最終更新日: 2024-05-01)

• 主引用文献: Verschueren, K.H.G.,Blanchet, C.,Felix, J.,Dansercoer, A.,De Vos, D.,Bloch, Y.,Van Beeumen, J.,Svergun, D.,Gutsche, I.,Savvides, S.N.,Verstraete, K.; Structure of ATP citrate lyase and the origin of citrate synthase in the Krebs cycle.; Nature, 568:571-575, 2019; PubMed: 30944476; DOI: 10.1038/s41586-019-1095-5

実験手法

X-RAY DIFFRACTION (1.3 Å)