6HX8

Tubulin-STX3451 complex

Summary for 6HX8

• Entry DOI: 10.2210/pdb6hx8/pdb
• Descriptor: Tubulin alpha-1B chain, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... (12 entities in total)
• Functional Keywords: cell cycle, tubulin fold, cytoskeleton, microtubule
• Biological source: Rattus norvegicus (Norway rat); More
• Total number of polymer chains: 6
• Total formula weight: 265440.94

Authors

Dohle, W.,Prota, A.E.,Menchon, G.,Hamel, E.,Steinmetz, M.O.,Potter, B.V.L. (deposition date: 2018-10-16, release date: 2019-02-27, Last modification date: 2024-01-24)

• Primary citation: Dohle, W.,Prota, A.E.,Menchon, G.,Hamel, E.,Steinmetz, M.O.,Potter, B.V.L.; Tetrahydroisoquinoline Sulfamates as Potent Microtubule Disruptors: Synthesis, Antiproliferative and Antitubulin Activity of Dichlorobenzyl-Based Derivatives, and a Tubulin Cocrystal Structure.; ACS Omega, 4:755-764, 2019; PubMed: 30775645; DOI: 10.1021/acsomega.8b02879

Experimental method

X-RAY DIFFRACTION (2.402 Å)