6HX8

Tubulin-STX3451 complex

6HX8 の概要

• エントリーDOI: 10.2210/pdb6hx8/pdb
• 分子名称: Tubulin alpha-1B chain, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... (12 entities in total)
• 機能のキーワード: cell cycle, tubulin fold, cytoskeleton, microtubule
• 由来する生物種: Rattus norvegicus (Norway rat); 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 265440.94

構造登録者

Dohle, W.,Prota, A.E.,Menchon, G.,Hamel, E.,Steinmetz, M.O.,Potter, B.V.L. (登録日: 2018-10-16, 公開日: 2019-02-27, 最終更新日: 2024-01-24)

• 主引用文献: Dohle, W.,Prota, A.E.,Menchon, G.,Hamel, E.,Steinmetz, M.O.,Potter, B.V.L.; Tetrahydroisoquinoline Sulfamates as Potent Microtubule Disruptors: Synthesis, Antiproliferative and Antitubulin Activity of Dichlorobenzyl-Based Derivatives, and a Tubulin Cocrystal Structure.; ACS Omega, 4:755-764, 2019; PubMed: 30775645; DOI: 10.1021/acsomega.8b02879

実験手法

X-RAY DIFFRACTION (2.402 Å)