6HWO
Crystal structure of human phosphodiesterase 4D2 catalytic domain with inhibitor NPD-1335
Summary for 6HWO
Entry DOI | 10.2210/pdb6hwo/pdb |
Related | 6GXQ |
Descriptor | cAMP-specific 3',5'-cyclic phosphodiesterase 4D, 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, ... (9 entities in total) |
Functional Keywords | phosphodiesterase, hydrolase, camp hydrolysis, alternative splicing |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 4 |
Total formula weight | 174297.70 |
Authors | Singh, A.K.,Brown, D.G. (deposition date: 2018-10-12, release date: 2019-07-24, Last modification date: 2024-01-24) |
Primary citation | de Heuvel, E.,Singh, A.K.,Boronat, P.,Kooistra, A.J.,van der Meer, T.,Sadek, P.,Blaazer, A.R.,Shaner, N.C.,Bindels, D.S.,Caljon, G.,Maes, L.,Sterk, G.J.,Siderius, M.,Oberholzer, M.,de Esch, I.J.P.,Brown, D.G.,Leurs, R. Alkynamide phthalazinones as a new class of TbrPDEB1 inhibitors (Part 2). Bioorg.Med.Chem., 27:4013-4029, 2019 Cited by PubMed: 31378593DOI: 10.1016/j.bmc.2019.06.026 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.99 Å) |
Structure validation
Download full validation report