6HWC
Yeast 20S proteasome beta2-G45A mutant
Summary for 6HWC
Entry DOI | 10.2210/pdb6hwc/pdb |
Related | 5CZ4 |
Descriptor | Proteasome subunit alpha type-2, Proteasome subunit beta type-4, PROTEASOME SUBUNIT BETA TYPE-5, ... (19 entities in total) |
Functional Keywords | proteasome, mutant, hydrolase |
Biological source | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) More |
Total number of polymer chains | 28 |
Total formula weight | 731635.47 |
Authors | Huber, E.M.,Groll, M. (deposition date: 2018-10-11, release date: 2019-01-30, Last modification date: 2024-01-24) |
Primary citation | Xin, B.T.,Huber, E.M.,de Bruin, G.,Heinemeyer, W.,Maurits, E.,Espinal, C.,Du, Y.,Janssens, M.,Weyburne, E.S.,Kisselev, A.F.,Florea, B.I.,Driessen, C.,van der Marel, G.A.,Groll, M.,Overkleeft, H.S. Structure-Based Design of Inhibitors Selective for Human Proteasome beta 2c or beta 2i Subunits. J.Med.Chem., 62:1626-1642, 2019 Cited by PubMed: 30657666DOI: 10.1021/acs.jmedchem.8b01884 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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