6HVF

Kinase domain of cSrc in complex with compound 29B

Summary for 6HVF

• Entry DOI: 10.2210/pdb6hvf/pdb
• Descriptor: Proto-oncogene tyrosine-protein kinase Src, ~{N}-[3-[3-ethyl-6-[4-(4-methylpiperazin-1-yl)phenyl]-4-oxidanylidene-7~{H}-pyrrolo[2,3-d]pyrimidin-5-yl]phenyl]prop-2-enamide, 1,2-ETHANEDIOL, ... (4 entities in total)
• Functional Keywords: kinase inhibitor, covalent inhibitor, transferase
• Biological source: Gallus gallus (Chicken)
• Total number of polymer chains: 2
• Total formula weight: 66696.96

Authors

Keul, M.,Mueller, M.P.,Rauh, D. (deposition date: 2018-10-10, release date: 2019-10-23, Last modification date: 2020-01-01)

• Primary citation: Lategahn, J.,Keul, M.,Klovekorn, P.,Tumbrink, H.L.,Niggenaber, J.,Muller, M.P.,Hodson, L.,Flasshoff, M.,Hardick, J.,Grabe, T.,Engel, J.,Schultz-Fademrecht, C.,Baumann, M.,Ketzer, J.,Muhlenberg, T.,Hiller, W.,Gunther, G.,Unger, A.,Muller, H.,Heimsoeth, A.,Golz, C.,Blank-Landeshammer, B.,Kollipara, L.,Zahedi, R.P.,Strohmann, C.,Hengstler, J.G.,van Otterlo, W.A.L.,Bauer, S.,Rauh, D.; Inhibition of osimertinib-resistant epidermal growth factor receptor EGFR-T790M/C797S.; Chem Sci, 10:10789-10801, 2019; PubMed: 31857889; DOI: 10.1039/c9sc03445e

Experimental method

X-RAY DIFFRACTION (2.1 Å)