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6HVA

Yeast 20S proteasome with human beta2i (1-53) in complex with 13

Summary for 6HVA
Entry DOI10.2210/pdb6hva/pdb
Related5CZ4
DescriptorProteasome subunit alpha type-2, Proteasome subunit beta type-4, Proteasome subunit beta type-5, ... (18 entities in total)
Functional Keywordsproteasome, mutant, inhibitor, binding analysis, hydrolase
Biological sourceHomo sapiens (Human)
More
Total number of polymer chains28
Total formula weight732493.63
Authors
Huber, E.M.,Groll, M. (deposition date: 2018-10-10, release date: 2019-01-30, Last modification date: 2024-01-24)
Primary citationXin, B.T.,Huber, E.M.,de Bruin, G.,Heinemeyer, W.,Maurits, E.,Espinal, C.,Du, Y.,Janssens, M.,Weyburne, E.S.,Kisselev, A.F.,Florea, B.I.,Driessen, C.,van der Marel, G.A.,Groll, M.,Overkleeft, H.S.
Structure-Based Design of Inhibitors Selective for Human Proteasome beta 2c or beta 2i Subunits.
J.Med.Chem., 62:1626-1642, 2019
Cited by
PubMed: 30657666
DOI: 10.1021/acs.jmedchem.8b01884
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.9 Å)
Structure validation

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