6HRZ

EthR2 in complex with compound 4 (BDM72170)

Summary for 6HRZ

Entry DOI	10.2210/pdb6hrz/pdb
Descriptor	Probable transcriptional regulatory protein, 1-(1,3-benzothiazol-2-yl)guanidine (3 entities in total)
Functional Keywords	helix-turn-helix, tetr-family, complex, inhibitor, drug design, tuberculosis, ethionamide, dna binding protein
Biological source	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Total number of polymer chains	2
Total formula weight	48629.62
Authors	Wintjens, R.,Wohlkonig, A.,Tanina, A. (deposition date: 2018-09-28, release date: 2019-02-27, Last modification date: 2024-01-24)
Primary citation	Prevet, H.,Moune, M.,Tanina, A.,Kemmer, C.,Herledan, A.,Frita, R.,Wohlkonig, A.,Bourotte, M.,Villemagne, B.,Leroux, F.,Gitzinger, M.,Baulard, A.R.,Deprez, B.,Wintjens, R.,Willand, N.,Flipo, M. A fragment-based approach towards the discovery of N-substituted tropinones as inhibitors of Mycobacterium tuberculosis transcriptional regulator EthR2. Eur J Med Chem, 167:426-438, 2019 Cited by PubMed: 30784877 DOI: 10.1016/j.ejmech.2019.02.023 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.57 Å)

Structure validation