6HRY
EthR2 in complex with compound 3 (BDM72719)
Summary for 6HRY
| Entry DOI | 10.2210/pdb6hry/pdb |
| Descriptor | Probable transcriptional regulatory protein, 1-(6-methylpyridin-2-yl)-3-propyl-urea (3 entities in total) |
| Functional Keywords | helix-turn-helix, tetr-family, complex, inhibitor, drug design, tuberculosis, ethionamide, dna binding protein |
| Biological source | Mycobacterium tuberculosis H37Rv |
| Total number of polymer chains | 2 |
| Total formula weight | 48631.63 |
| Authors | Wintjens, R.,Wohlkonig, A.,Tanina, A. (deposition date: 2018-09-28, release date: 2019-02-27, Last modification date: 2024-01-24) |
| Primary citation | Prevet, H.,Moune, M.,Tanina, A.,Kemmer, C.,Herledan, A.,Frita, R.,Wohlkonig, A.,Bourotte, M.,Villemagne, B.,Leroux, F.,Gitzinger, M.,Baulard, A.R.,Deprez, B.,Wintjens, R.,Willand, N.,Flipo, M. A fragment-based approach towards the discovery of N-substituted tropinones as inhibitors of Mycobacterium tuberculosis transcriptional regulator EthR2. Eur J Med Chem, 167:426-438, 2019 Cited by PubMed: 30784877DOI: 10.1016/j.ejmech.2019.02.023 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.84 Å) |
Structure validation
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