6HOY

Human Sirt6 in complex with ADP-ribose and the inhibitor trichostatin A

6HOY の概要

• エントリーDOI: 10.2210/pdb6hoy/pdb
• 分子名称: NAD-dependent protein deacetylase sirtuin-6, [(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL [HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE, ZINC ION, ... (8 entities in total)
• 機能のキーワード: deacylase, inhibitor, hydroxamate, non-competitive, isoform-selective, hydrolase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 70364.47

構造登録者

You, W.,Steegborn, C. (登録日: 2018-09-18, 公開日: 2018-11-14, 最終更新日: 2024-01-24)

• 主引用文献: You, W.,Steegborn, C.; Structural Basis of Sirtuin 6 Inhibition by the Hydroxamate Trichostatin A: Implications for Protein Deacylase Drug Development.; J.Med.Chem., 61:10922-10928, 2018; PubMed: 30395713; DOI: 10.1021/acs.jmedchem.8b01455

実験手法

X-RAY DIFFRACTION (1.7 Å)