6HOV

Crystal Structure of BRD4 first bromodomain in complex with ferulic acid

Summary for 6HOV

• Entry DOI: 10.2210/pdb6hov/pdb
• Related: 6HOQ
• Descriptor: Bromodomain-containing protein 4, 1,2-ETHANEDIOL, 3-(4-HYDROXY-3-METHOXYPHENYL)-2-PROPENOIC ACID, ... (4 entities in total)
• Functional Keywords: four helical bundle, transcription
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 15417.70

Authors

Dalle Vedove, A.,Lolli, G. (deposition date: 2018-09-18, release date: 2019-10-09, Last modification date: 2024-01-24)

• Primary citation: Cozza, G.,Zonta, F.,Dalle Vedove, A.,Venerando, A.,Dall'Acqua, S.,Battistutta, R.,Ruzzene, M.,Lolli, G.; Biochemical and cellular mechanism of protein kinase CK2 inhibition by deceptive curcumin.; Febs J., 287:1850-1864, 2020; PubMed: 31661600; DOI: 10.1111/febs.15111

Experimental method

X-RAY DIFFRACTION (1.85 Å)