6HO9

TRANSCRIPTIONAL REPRESSOR ETHR FROM MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH BDM44825

Summary for 6HO9

Entry DOI	10.2210/pdb6ho9/pdb
Descriptor	HTH-type transcriptional regulator EthR, 4-[4-(2-methylpropyl)-1,2,3-triazol-1-yl]-~{N}-[3,3,3-tris(fluoranyl)propyl]benzamide (3 entities in total)
Functional Keywords	helix-turn-helix, dna binding protein, tetr-family, complex, inhibitor, drug design, tuberculosis, ethionamide
Biological source	Mycobacterium tuberculosis CDC1551
Total number of polymer chains	1
Total formula weight	25268.32
Authors	Wintjens, R.,Wohlkonig, A. (deposition date: 2018-09-17, release date: 2018-12-26, Last modification date: 2024-01-24)
Primary citation	Tanina, A.,Wohlkonig, A.,Soror, S.H.,Flipo, M.,Villemagne, B.,Prevet, H.,Deprez, B.,Moune, M.,Peree, H.,Meyer, F.,Baulard, A.R.,Willand, N.,Wintjens, R. A comprehensive analysis of the protein-ligand interactions in crystal structures of Mycobacterium tuberculosis EthR. Biochim Biophys Acta Proteins Proteom, 1867:248-258, 2018 Cited by PubMed: 30553830 DOI: 10.1016/j.bbapap.2018.12.003 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation