6HMO

Solution structure of the RNA duplex formed by the 5'-end of U1snRNA and the 5'-splice site of SMN2 exon7 in complex with the SMN-C5 splicing modifier

Summary for 6HMO

DescriptorRNA (5'-R(*AP*UP*AP*CP*(PSU)P*(PSU)P*AP*CP*CP*UP*G)-3'), RNA (5'-R(*GP*GP*AP*GP*UP*AP*AP*GP*UP*CP*U)-3'), 2-(8-fluoranyl-2-methyl-imidazo[1,2-a]pyridin-6-yl)-7-(4-methylpiperazin-1-yl)pyrido[1,2-a]pyrimidin-4-one (3 entities in total)
Functional Keywords5'-splice site bulge repair, u1 snrna, spinal muscular atrophy, bulge nucleotide, splicing modifier, rna
Biological sourceHomo sapiens
Total number of polymer chains2
Total molecular weight7367.67
Authors
Campagne, S.,Allain, F.H. (deposition date: 2018-09-12, release date: 2019-08-14)
Primary citation
Campagne, S.,Boigner, S.,Rudisser, S.,Moursy, A.,Knorlein, A.,Hall, J.,Ratni, H.,Clery, A.,Allain, F.H.
Structural basis for specific RNA splicing correction induced by a small molecule
To Be Published,
Experimental method
SOLUTION NMR
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Structure validation

ClashscoreRNA backbone0 0.82MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all NMR structures