Solution structure of the RNA duplex formed by the 5'-end of U1snRNA and the 5'-splice site of SMN2 exon7 in complex with the SMN-C5 splicing modifier

Summary for 6HMO

DescriptorRNA (5'-R(*AP*UP*AP*CP*(PSU)P*(PSU)P*AP*CP*CP*UP*G)-3'), RNA (5'-R(*GP*GP*AP*GP*UP*AP*AP*GP*UP*CP*U)-3'), 2-(8-fluoranyl-2-methyl-imidazo[1,2-a]pyridin-6-yl)-7-(4-methylpiperazin-1-yl)pyrido[1,2-a]pyrimidin-4-one (3 entities in total)
Functional Keywords5'-splice site bulge repair, u1 snrna, spinal muscular atrophy, bulge nucleotide, splicing modifier, rna
Biological sourceHomo sapiens
Total number of polymer chains2
Total molecular weight7367.67
Campagne, S.,Allain, F.H. (deposition date: 2018-09-12, release date: 2019-08-14)
Primary citation
Campagne, S.,Boigner, S.,Rudisser, S.,Moursy, A.,Knorlein, A.,Hall, J.,Ratni, H.,Clery, A.,Allain, F.H.
Structural basis for specific RNA splicing correction induced by a small molecule
To Be Published,
Experimental method

Structure validation

ClashscoreRNA backbone0 0.82MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all NMR structures