6HM7
CRYSTAL STRUCTURE OF SPLEEN TYROSINE KINASE (SYK) IN COMPLEX WITH A 2-(PHENOXYMETHYL)PYRIDINE INHIBITOR
Summary for 6HM7
Entry DOI | 10.2210/pdb6hm7/pdb |
Related | 6HM6 |
Descriptor | Tyrosine-protein kinase SYK, 7-[2-methoxy-6-[(4-methylpyridin-2-yl)methoxy]phenyl]-2,3,4,5-tetrahydro-1~{H}-3-benzazepine, BROMIDE ION, ... (6 entities in total) |
Functional Keywords | sk363, syk, non-receptor tyrosine kinase, spleen tyrosine kinase, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 32889.35 |
Authors | Somers, D.O. (deposition date: 2018-09-12, release date: 2018-10-10, Last modification date: 2024-05-01) |
Primary citation | Barker, M.D.,Liddle, J.,Atkinson, F.L.,Wilson, D.M.,Dickson, M.C.,Ramirez-Molina, C.,Lewis, H.,Davis, R.P.,Somers, D.O.,Neu, M.,Jones, E.,Watson, R. Discovery of potent and selective Spleen Tyrosine Kinase inhibitors for the topical treatment of inflammatory skin disease. Bioorg. Med. Chem. Lett., 28:3458-3462, 2018 Cited by PubMed: 30249354DOI: 10.1016/j.bmcl.2018.09.022 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.64 Å) |
Structure validation
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